Aha development

Richard Harland (UC Berkeley) 1: Early Frog Development: How to Make a Tadpole

laevis, is an excellent model to study vertebrate development. Richard Harland outlines frog development including the cell movements and molecular signals of gastrulation. Talk Overview:Richard Harland begins his talk by asking how a fertilized egg goes from a single cell to a complex, multicellular organism during vertebrate development.  He explains that amphibians, and in particular Xenopus laevis, are an excellent system for addressing this question.  For example, early experiments by Spemann and Mangel in newt embryos were the first to demonstrate the presence of an “organizer” region, and more recent studies in Xenopus have identified many signaling molecules that control embryogenesis. Throughout his talk, Harland shows stunning movies to illustrate the beauty and complexity of early frog development.During the gastrulation, cell movements result in a massive reorganization of the embryo from a simple spherical ball of cells, the blastula, into a multi-layered organism. In his second video, Harland simplifies this complex phase of frog development by breaking it down into 7 separate steps and describing the specific cell rearrangements associated with each step. In his last talk, Harland introduces the signaling molecules responsible for specifying distinct tissues in the embryo.  He explains how gradients of signaling molecules, such as β-catenin and Nodal, are initially set up in the egg and how these gradients induce the formation of the mesoderm layer. He also describes classic experiments from the 1990s showing that the organizer is necessary to pattern the mesoderm into tissues such as muscle and neural plate. Harland then focuses on experiments from his lab that identified the molecules expressed in the organizer that specify dorsal cell fate.  Speaker Biography:Richard Harland is the C. H. Li Distinguished Professor of Molecular and Cellular Biology at the University of California, Berkeley where his lab studies early vertebrate development in both Xenopus and in mice. As a PhD student, Harland studied DNA replication in the lab of Dr. Ron Laskey at the MRC Laboratory of Molecular Biology, Cambridge. He moved to the USA, and began his studies of vertebrate development, as a post-doc with Harold Weintraub at the Fred Hutchinson Cancer Research Center. In 1985, Harland joined the faculty at UC Berkeley. As well as running a successful research lab, Harland is an integral member of the developmental biology community.  He has played an important role in the project to sequence the Xenopus tropicalis and X. laevis genomes. He has taught in the Marine Biological Lab Embryology course for over 15 years and he co-authored the textbook “Early Development of Xenopus laevis: A Laboratory Manual”.  His contributions to science and teaching have been recognized with the award of the E.G. Conklin Medal from the Society for Developmental Biology and election to the National Academy of Sciences. Learn more about Harland’s lab here:

Nikhil Niks


D'Arcy Panziera

Anyone else disappointed that Plastic Golf Club Battle 2 never happened?

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The 1 & only

Who is watching this in 2017

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Margaret B

Trust abilities after being cheated on is serious

He lived a good life.

Lightning Larry

Does the one where the Orochi says "Get out of my Swamp" in the first mission of the Samurai campaign count as a Shrek Reference?


i think the face was jesse pinkmon BITCH


Teens react anyone?


Call child protective services!!!


Wow.... I thought it’d be something better than that like

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262th like

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Shahim Ali

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"always takes longer" bruh i was good with my mom it only last her 40 minutes

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Anyone think this is sponsored by Hearthstone? Just me? Okay.

Curtiss Maude

93 thumbs down? who? why?

Nolan Porter

You denying it so fast makes me think he is the panda!


3:59 I might have just hopped out my seat and punched him in the face after he said that

MVK - San

I stole many things.

Chimble, Master of Chimney

that first one was a reference to that one scene in the Metal Gear Solid V: Phantom Pain trailer scene where Big Boss/Naked Snake/whatever-he's-called-now found Kaz and put his sunglasses on! Kojima was even wearing Kaz's sunglasses at first


does anyone else hear animals by nickelback at the beggining?

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Sydelle Mutabaruka

This would make a great movie.

leroy woodcook

You guys should do an airsoft battle


can't wait to watch this in the cinema with fucking toddlers kicking my seat


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